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In what reads like science fiction, a new study published in the journal ACS Central Science reports the development of bandages that detect the presence of bacteria in wounds and change color, depending on whether they are drug-sensitive or drug-resistant. This is an important step in helping patients recover better. There are also bandages for specific uses, like orthopedic bandage, and fixation bandage.
Drug resistance – the problem
Drug resistance is among the greatest threats to worldwide health. If bacterial infections could be sensed early enough to treat them before they take a hold on the patient, it would help avoid serious infections. And if the bacteria resist the antibiotic, being able to detect this would be crucial in switching drugs to arrest the infection before it spreads.
At present, the methods of detecting antibiotic resistance are expensive, require professional expertise, and take too much time. Moreover, using antibiotics for infections that are resistant to them promotes even more drug resistance.
Colorimetric methods to the rescue
The new study describes a way of doing just this, based on a color-changing material. Described as “a portable paper-based band-aid (PBA)”, it is a colorimetric way of sensing and treating sensitive bacterial infections while signaling the presence of drug-resistant bacteria as well.
Early detection of infection in this study exploits the microenvironment of bacterial growth, which includes an acidic pH, various toxins and enzymes. Acidity is an easy way to track the presence of pathogenic bacteria because it is due to their breakdown of glucose. Drug resistance, on the other hand, depends on the presence of the beta-lactamase and similar enzymes. The presence of beta-lactamase is a widely used indicator of bacterial antibiotic resistance because it denotes resistance to the extremely common beta-lactam antibiotics.
Once drug resistance has been identified, photodynamic therapy and other similar treatments have been adopted to increase the level of reactive oxygen species (ROS). These molecules act on multiple cell targets associated with drug resistance, including the bacterial cell wall, nucleic acids, and proteins. A careful use of this strategy is necessary since ROS attack healthy cells and bacteria indiscriminately.
The innovation
The need of the hour is a portable, cheap and accurate device to detect and overcome antibiotic resistance. Paper-based platforms, including biosensors and sterilization paper, have stolen the limelight in this regard because of multiple advantages: low cost, sustainability, safety, and ease of adjustment. The current study focuses on a paper-based bandage device to detect and treat infection selectively after sensing antibiotic resistance.
The basis of the bandage is colorimetry. And tapes and plasters are also needed. It contains bromyothymol B that is green at first but becomes yellow on encountering acids that are found in the microenvironment of a bacterial infection. In this situation, the material releases an antibiotic, ampicillin, loaded on nanoparticles and coated with the sugar chitosan that attracts bacteria due to their negative charge. When the nanoparticles come into contact with the acid environment, they release the drug. If the bacteria are sensitive to this drug, they will be killed. If otherwise, they secrete beta-lactamase to inactivate the drug. This enzyme acts on the yellow molecule nitrocefin to turn it red.
If the bandage for first aid becomes red, the researchers will pass light through the bandage, which stimulates the production of reactive oxygen species from a metallo-organic compound called PCN-224, built on a porphyrin base, and which has high photodynamic properties, releasing a flood of ROS in response to light. These inhibit or weaken the bacteria, increasing their susceptibility to the drug. Thus, the tubular bandage has been proved to accelerate wound healing in mice after introducing both drug-sensitive and drug-resistant bacteria into the wounds.
HOW TO CARE FOR RAW OPEN SKIN WOUNDS?
All raw wounds will heal if there is enough blood supply to the area, and if the raw tissues are not allowed to “dry and die.” Open raw wounds will heal with proper care even if there is exposed fat, bone, tendon, muscle, or joint. Red is raw; pink is healed. If the wound is red, it has lost the waterproof barrier of skin and it is an open or raw wound that oozes liquid as our bodies are 80% water. The most important part of the care of raw wounds is to keep them clean and greasy so the tissues do not dry and die. Wounds all over the body can be treated in this manner. Below, we illustrate 4 typical case examples where we use this approach in complex wounds of the foot, hand, fingertips,2 and face with exposed bone, cartilage, joints, and tendons. In some cases, if there are deep, open, caved in wounds, we add a vacuum assisted wound dressing to accelerate flattening the cave.
What Kind of Operation Bandage Do We Need for Wounds?
Dressings do not need to be sterile, just clean.6 Sterile dressings are expensive and unnecessary. Coban tape off the roll is a good clean dressing that can be directly applied over grease on fingers and leg wounds.2 Panty liners, sanitary napkins, and diapers out of the package are another good source of clean inexpensive dressings.7 Every day, the old dressing is removed and the patient gets in the shower to let clean water run over the wound. After the shower, grease is applied thickly to a clean bandage. That is placed on the wound to pad it, protect it, and keep it moist until tomorrow
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Topics and categories on The BidAmount Asian Art Forum | Chinese Art
Kangxi vases, Kangxi dishes and chargers, Kangxi ritual pieces, Kangxi scholar's objects, Qianlong famille rose, Qianlong enamels, Qianlong period paintings, Qianlong Emporer's court, Fine porcelain of the Yongzheng period. Chinese imperial art, Ming porcelain including Jiajing, Wanli, Xuande, Chenghua as well as Ming jades and bronzes.
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The BidAmount Asian Art Forum | Chinese Art
A free Asian art discussion board and Asian art message board for dealers and collectors of art and antiques from China, Japan, Korea, Thailand, Cambodia, Vietnam and the rest of Asia. Linked to all of the BidAmount Asian art reference areas, with videos from plcombs Asian Art and Bidamount on YouTube. Sign up also for the weekly BidAmount newsletter and catalogs of active eBay listing of Chinese porcelain, bronze, jades, robes, and paintings.
The art of calligraphy - and for the ancient Chinese it certainly was an art - aimed to demonstrate superior control and skill using brush and ink. Calligraphy established itself as one of the major Chinese art forms during the Han dynasty (206 BCE - 220 CE), and for two millennia after, all educated men were expected to be proficient at it.
The Museum’s collections of Asian art span nearly five millennia and encompass the cultures of China, the Himalayas, India, Japan, Korea, and Southeast Asia. In 2007, the Museum launched an initiative to create dedicated galleries for the collection, beginning with a gallery for the arts of Korea ...
Chinese art is full of symbolism, in that artists typically seek to depict some aspect of a totality of which they are intuitively aware.
China Online Museum is the finest online museum of Chinese art. It features Chinese calligraphy, painting, ceramics, bronzes, carving, and other artworks.
Chinese Ceramics & Works of Art. Overview Upcoming auctions Contacts Auction results ... Christie’s sales of Chinese ceramics and works of art showcase centuries of Chinese history. Held throughout the year in London, New York, Paris and Hong Kong, they attract a wide audience of collectors and connoisseurs vying for pieces as diverse as ...
Explore Asian Art Week. Contact the Specialist Department. Chinese Paintings ... Senior Specialist, Head of Sale. ehammer@christies.com. Tel:+1 212 641 5760. Bid in-person or online for the upcoming auction:Fine Chinese Paintings on 10 September 2019 at New York. Bid in-person or online for the upcoming auction:Fine Chinese Paintings on 10 ...
Discover an abundance of must-see art from all corners of a vast continent at Christie’s NY Asian Art Week. From contemporary classical and Chinese paintings to works with exemplary provenance from the Art Institute of Chicago, our Rockefeller Paza galleries will be full of ancient treasures and contemporary masterworks in a salute to the vibrant arts of Asia.
Sold to benefit The Art Institute of Chicago’s Asian Art Acquisition Fund, the sale features 84 lots with a focus on Ming and Qing porcelains, and offers a rare insight into the taste for collecting Chinese ceramics and works of art in the Midwest from the end of the 19th century through the 1980s. Highlights include two Wanli wucai garlic-head vases, a Qianlong mark and period, blue and ...
Specialist, Chinese Paintings, Christie's London Dr Malcolm McNeill is a Specialist in Chinese Paintings at Christie’s, based in London. He previously worked as an assistant curator of the Chinese collections and the Victoria and Albert Museum in London, as a researcher at the British Museum, and as a translator and tour guide at the National Palace Museum in Taipei.
The Christie's Education 2020 Conference: The Chinese Art Market 18 Jun 2019 Christie’s Education is delighted to announce our first international academic conference in Asia which will take place in Hong Kong from 26-27 November 2020 at the Hong Kong Convention and Exhibition Centre and will run in parallel with Christie’s Hong Kong Autumn Auctions.
The summer Chinese Art sale in Hong Kong will feature works of art from several private collections, including Qing porcelains and textile from the collection of the legendary Chinese art dealer A. W. Bahr (1877–1959), fine gilt bronze Buddhist sculptures from an old Hong Kong collection, an East Asian collection of Qing dynasty wine cups and jades, and a Japanese collection of Song ceramics ...
Sotheby's Chinese Works of Art Department holds two auctions each year in London, New York, Hong Kong and Paris.
Chinese Art - View Auction details, bid, buy and collect the various artworks at Sothebys Art Auction House.
With more than 340 Chinese works of art dating from the Neolithic to the Republic periods, highlights of this sale include a selection of Qing Imperial monochromes from the collection of Arnold and Blema Steinberg, early ceramics from the Art Institute of Chicago and Chinese porcelain and works of art from the collection of Henry Arnhold.
Results: Sotheby's Asia Week achieved $52.4 million in six strong auctions, exceeding pre-sale estimates. With 76.5% of lots sold and 60.3% of lots surpassing high estimates, the Asian art sales at Sotheby's indicate continued collector interest in the finest works of art from China, India and and the Himalayas.
Today's sale of Important Chinese Art will proceed as planned with sessions at 10 AM and 2 PM EDT. Sotheby's will be monitoring the weather conditions throughout the day and will be available to coordinate alternative bidding options should conditions make it difficult for clients to attend the auction in person.
Bonhams Chinese Art department is renowned for offering the finest works of art representing the richness and breadth of China's artistic heritage, particularly Imperial porcelain, white and spinach green jades, cloisonné and Buddhist art. Specialised international auctions are held globally, including London, Hong Kong and San Francisco.
Bonhams : Chinese Works of Art We use cookies to remember choices you make on functionality and personal features to enhance your experience to our site. By continuing to use our site you consent to the use of cookies. Please refer to our privacy and cookie policies for more information.
Bonhams Fine Art Auctioneers & Valuers: auctioneers of art, pictures, collectables and motor cars. We use cookies to remember choices you make on functionality and personal features to enhance your experience to our site. By continuing to use our site you consent to the use of cookies. ... Chinese Art (US) General enquiries
Bonhams : Fine Chinese Art We use cookies to remember choices you make on functionality and personal features to enhance your experience to our site. By continuing to use our site you consent to the use of cookies. Please refer to our privacy and cookie policies for more information.
Bonhams Fine Art Auctioneers & Valuers: auctioneers of art, pictures, collectables and motor cars Bonhams : Asian Art We use cookies to remember choices you make on functionality and personal features to enhance your experience to our site.
Bonhams are international auctioneers of fine Chinese and Japanese art. We specialise in rare Imperial and Export Chinese ceramics and works of art, as well as Japanese ceramics, fine and decorative works of art from the Neolithic Period to the 20th century. View on map
Bonhams Fine Art Auctioneers & Valuers: auctioneers of art, pictures, collectables and motor cars. We use cookies to remember choices you make on functionality and personal features to enhance your experience to our site. By continuing to use our site you consent to the use of cookies. ... Asian Art Bonhams. Work. 22 Queen St.